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Cancer caused by stem cells

Lordknukle
Posts: 12,788
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9/14/2013 9:14:08 PM
Posted: 3 years ago
Increasingly, there has been evidence found for the notion that cancer is actually a result of the inability for stem cells to differentiate, instead of the uncontrollable growth of normal cells.

"Professor Ian Mackenzie points to a little jumble of cells on a computer screen and smiles.
"They"re cancer stem cells," he says. "Not everyone in medicine believes in them yet, but look " there they are."

Even to the untrained eye, it"s clear there are two distinct types of cell; one that groups together a little like frogspawn, and another that looks like a slug.

Stem cells, which are found in tissue all over the body, can grow into every kind of cell, including bone, skin and blood cells

"If you watched the slug-like one for long enough, you"d see it move," says the professor.
"We believe this type of stem cell facilitates the spread of cancer and that the other is responsible for the growth of tumours and for making them return after you think your cancer has gone away."

In Professor Mackenzie"s laboratory at Barts and the London Medical School"s Blizard Institute, researchers are busy extracting these cells from tumours.

Their work represents a potentially extraordinary new approach to the disease.

The traditional view among oncologists is that cancerous tumours are the result of genetic mutations within ordinary cells that cause them to divide uncontrollably and then spread.

However, evidence has been mounting that small numbers of stem cells within tumours actually orchestrate their growth and proliferation.

But these types of cell are difficult to eradicate with traditional chemo and radiotherapy " they actually come equipped with pump-like mechanisms on their surface that filter medicines away " and they can re-grow even after the primary tumour has been destroyed or removed.

So, runs the latest thinking, if you could kill them, you could kill cancer."
http://www.dailymail.co.uk...
"Easy is the descent to Avernus, for the door to the Underworld lies upon both day and night. But to retrace your steps and return to the breezes above- that's the task, that's the toil."
Jack212
Posts: 572
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9/15/2013 6:10:59 PM
Posted: 3 years ago
Everything is orchestrated by stem cells, so be careful how you interpret this article.
Lordknukle
Posts: 12,788
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9/15/2013 6:16:12 PM
Posted: 3 years ago
At 9/15/2013 6:10:59 PM, Jack212 wrote:
Everything is orchestrated by stem cells, so be careful how you interpret this article.

I was watching one of the Great Courses on anatomy and the Dr. said that one of the prerequisites for cancer is the inability of stem cells to differentiate into normal cells. He said that normal cells cannot become cancerous, which seemed weird because that's exactly what I've heard. As it turns out, he was espousing the new "thing" in oncological medicine.
"Easy is the descent to Avernus, for the door to the Underworld lies upon both day and night. But to retrace your steps and return to the breezes above- that's the task, that's the toil."