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Breaking cycle of obesity

slo1
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12/30/2013 11:45:49 AM
Posted: 2 years ago
http://www.sciencedaily.com...

Next month, scientists at U-M will begin a placebo-controlled clinical trial of amlexanox to test its efficacy as a drug for treating obesity and diabetes in humans. Formulations of amlexanox are prescribed in different international markets to treat asthma and canker sores.

Obesity leads to a state of chronic, low-grade inflammation in liver and fat tissue. Scientists believe that inflammation links obesity and insulin resistance via a pathway called NFkB, which is involved in the regulation of a range of cellular processes and activated in obesity.

Activation of NFkB increases the levels of a pair of genes, IKK^9; and TBK1, which in turn reduce the ability of certain receptors in the fat cells of obese mice to respond to catecholamines like adrenaline, "fat-burning" hormones generated by the sympathetic nervous system in response to stress.

"We've suspected that in obesity, fat cells become less sensitive to catecholamines such as adrenaline, and that this reduced sensitivity in turn reduces energy expenditure, but the details of this haven't been fully understood," Saltiel said.
High levels of IKK^9; and TBK1 also resulted in lower levels of a second messenger molecule called cAMP, which increases energy expenditure by elevating fat burning.
slo1
Posts: 4,361
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12/30/2013 11:48:28 AM
Posted: 2 years ago
Interesting read. It is becoming increasing clear that loosing weight is not always as simple as mind over matter, however, if the body is no longer responding to fat energy production when obese, it just adds to the importance of forcing it via exercise not to mention the need to not get to this point in the first place.