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First Structure of Infectious Prion Devleoped

slo1
Posts: 4,353
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9/12/2016 2:40:42 AM
Posted: 2 months ago
This pretty big news. The first model of the infectious prion, which is a misfolded protein that causes disease in humans, sheep, and cows. It is particularly scary as a misfolded infectious protein can not be made inert with heat. Once injested it sets off a chain reaction causing the misfold to replicate and disrupt cellular functioning.

http://www.the-scientist.com...

Protein folding is still a very mystery, simply from the number of combinations. Our computer processing power is still not robust enough to model it well.

Proteins can misfold and probably do regularly. it is not entirely understood. Recently it was demonstrated that a single copper ion can cause a misfold.

https://www.sciencedaily.com...

The body does have mechanism to find and degrade them so they don't build up in the body.

http://cysticfibrosisnewstoday.com...

While mad cow disease is very scary, it appears that checks and regulation in the food supply where cow brain matter potentially enters the food supply works well. None the less. The infectious diesases are very scary.

Understanding protein folding and how misfolds happen is key to eliminating many non-infectious (thought to be noninfectious) protein misfold disease such as Alzheimers, Parkinson, ALS. Here is a list of disease where protein misfolding plays a significant part in the disease and/or disease progression.
http://www.nature.com...
Quadrunner
Posts: 1,139
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9/16/2016 5:55:53 AM
Posted: 2 months ago
At 9/12/2016 2:40:42 AM, slo1 wrote:
This pretty big news. The first model of the infectious prion, which is a misfolded protein that causes disease in humans, sheep, and cows. It is particularly scary as a misfolded infectious protein can not be made inert with heat. Once injested it sets off a chain reaction causing the misfold to replicate and disrupt cellular functioning.

http://www.the-scientist.com...

Protein folding is still a very mystery, simply from the number of combinations. Our computer processing power is still not robust enough to model it well.

Proteins can misfold and probably do regularly. it is not entirely understood. Recently it was demonstrated that a single copper ion can cause a misfold.

https://www.sciencedaily.com...

The body does have mechanism to find and degrade them so they don't build up in the body.

http://cysticfibrosisnewstoday.com...

While mad cow disease is very scary, it appears that checks and regulation in the food supply where cow brain matter potentially enters the food supply works well. None the less. The infectious diesases are very scary.

Understanding protein folding and how misfolds happen is key to eliminating many non-infectious (thought to be noninfectious) protein misfold disease such as Alzheimers, Parkinson, ALS. Here is a list of disease where protein misfolding plays a significant part in the disease and/or disease progression.
http://www.nature.com...

That was a very good post. Thank you.
Wisdom is found where the wise seek it.
Axonly
Posts: 1,802
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9/16/2016 11:25:43 AM
Posted: 2 months ago
At 9/12/2016 2:40:42 AM, slo1 wrote:
This pretty big news. The first model of the infectious prion, which is a misfolded protein that causes disease in humans, sheep, and cows. It is particularly scary as a misfolded infectious protein can not be made inert with heat. Once injested it sets off a chain reaction causing the misfold to replicate and disrupt cellular functioning.

http://www.the-scientist.com...

Protein folding is still a very mystery, simply from the number of combinations. Our computer processing power is still not robust enough to model it well.

Proteins can misfold and probably do regularly. it is not entirely understood. Recently it was demonstrated that a single copper ion can cause a misfold.

https://www.sciencedaily.com...

The body does have mechanism to find and degrade them so they don't build up in the body.

http://cysticfibrosisnewstoday.com...

While mad cow disease is very scary, it appears that checks and regulation in the food supply where cow brain matter potentially enters the food supply works well. None the less. The infectious diesases are very scary.

Understanding protein folding and how misfolds happen is key to eliminating many non-infectious (thought to be noninfectious) protein misfold disease such as Alzheimers, Parkinson, ALS. Here is a list of disease where protein misfolding plays a significant part in the disease and/or disease progression.
http://www.nature.com...

I would like to add that all prion diseases are untreatable and fatal.
Meh!
Skepticalone
Posts: 6,130
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9/16/2016 1:28:24 PM
Posted: 2 months ago
At 9/12/2016 2:40:42 AM, slo1 wrote:
This pretty big news. The first model of the infectious prion, which is a misfolded protein that causes disease in humans, sheep, and cows. It is particularly scary as a misfolded infectious protein can not be made inert with heat. Once injested it sets off a chain reaction causing the misfold to replicate and disrupt cellular functioning.

http://www.the-scientist.com...

Protein folding is still a very mystery, simply from the number of combinations. Our computer processing power is still not robust enough to model it well.

Proteins can misfold and probably do regularly. it is not entirely understood. Recently it was demonstrated that a single copper ion can cause a misfold.

https://www.sciencedaily.com...

The body does have mechanism to find and degrade them so they don't build up in the body.

http://cysticfibrosisnewstoday.com...

While mad cow disease is very scary, it appears that checks and regulation in the food supply where cow brain matter potentially enters the food supply works well. None the less. The infectious diesases are very scary.

Understanding protein folding and how misfolds happen is key to eliminating many non-infectious (thought to be noninfectious) protein misfold disease such as Alzheimers, Parkinson, ALS. Here is a list of disease where protein misfolding plays a significant part in the disease and/or disease progression.
http://www.nature.com...

I always been fascinated with prions, as far as "are they life", but I was not aware they affect us in so many ways.
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