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Whenever large development occurs, part of a city cultural identity is lost or at least lessens. This is not necessarily an intentional change, but due to an influx of new workers, housing, etc the cultural make up of a region can alter. There are times where a cultural can be contained in a developed area such as china town, little italy, etc, but this is few and far between.
Human beings tend to develop better and better technology over time. Once human beings get past the hunting and gathering stage the development of cities are all but inevitable. Agriculture can support larger populations than hunting-gathering and people will tend to congregate to do things they couldn't do before. This happened in Europe, Asia, Africa and the Americas.