Brendan Fraser has proven that he is a very competent and talented actor who is capable of taking on complex and sophisticated roles. This ability coupled with his enormous popularity among the public will ensure that he will be given a fair opportunity to re-enter the movie business and it is likely that he will make a success of it.
Brendan Fraser must have a loyal fan base because they have been petitioning Hollywood on his behalf. Some stars have a short success and move on to other things. The comeback for Brendan will depend on how well his acting efforts are and if he is offered the right part. His petition will help to bring some attention to his name again.
Although, Brendan Fraser has had many successful roles in previous films, his greatest hits were largely in the 90's. A petition signed by roughly 7,400 people is not enough to warrant Hollywood shelling out large sums of money on the actor. Today's audiences want younger, more talented stars in their films.
People who liked Brendan Fraser back in the day mostly liked him because they were teenagers and they thought he was young and good looking. Fraser doesn't have a large base of fans. He doesn't have enough fans to have any real staying power as an older movie star. It just isn't going to work with older fans.