Yes, I believe Ben Roethlisberger's multiple 500+ passing yard games record is significant. With as many great quarterbacks in the league (Payton Manning, Tom Brady, Drew Brees and many more), Ben is the only one to hold this statistic. Add on top of the 500+ yards passing he got last night, 6 touchdown passes and you have a performance for the ages.
The quarterback has established himself as a record setter after his 500 plus passing yards helped Steelers beat Colts. The quarterback had completed this haul multiple times and is certain to remain a landmark for time to come for upcoming players as well as fellow professionals. The number will always remain a significant one and will be vary hard to achieve.
When sports analysts discuss the greatest quarterbacks in the NFL today, Ben Roethlisberger is not necessarily the first name that comes up. Yet even so, Roethlisberger record of having multiple games where he threw 500 or more passing yards is extremely impressive, and even more so given that none of the other great quarterbacks in the game have come close to surpassing his achievement.
No other quarterback has thrown for multiple 500+ yard games in the history of the NFL. Even the great Peyton Manning, who just this year shattered Brett Favre's record of 509 touchdowns, has not thrown for multiple 500+ yard games. No other active quarterback in the league besides Matt Schaub is close to breaking Ben Roethlisberger's record. Matt Schuab has a 527 yard passing game from 2012, but is no threat to breaking Ben Roethlisberger's record.