Goku would win in a fight against Vegeta. Goku is simply too powerful. A better question would be who would win between Goku and The Incredible Hulk. The Hulk's power continues to grow the more hurt and angry he is, so by amping up his power Goku would be in turn amping up The Incredible Hulk's power as well.
Goku is clearly much more superior to Vegta because he is way stronger and a way better fighter. Honestly, there is no comparison because 11 times out of 10, Goku would literally ruin Vegta. Goku is such a great fighter that he could literally take on 500 Vegtas and ruin all of them as well.