If we were living off the land like the Native American Indians we would be living a much more relaxed and comfortable life, but we would not have the populations that we have today. I do not think this is solely to blame on technological innovations, it's more to blame on the push for success or the need Americans seem to have to be successful. A lot has played into the hectic lifestyle we have created, it's certainly not necessary and there are valid alternatives, but people have to give up on material possessions to live those lifestyles.
I think if we had kept living like American Indians, we would be living much more comfortable and peaceful lives. Life is easier physically, but much more stressful. We were "designed" to handle physical stress and the harshness of the world. Now we have a billion ways to manifest stress.
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If we had forgone technological progress our lives would be short, and more often than not miserable. There are places in the world where the reach of technological civilization is minimal. One can see in terms of longevity and disease that we would not typically want to trade places with the inhabitants of these places.
Native American Indians had very difficult lives and I think we have become idealized about their life and the struggles people faced before technology. There is nothing simple or comfortable about hunting for all your food or struggling to live off the land. There is also nothing relaxing about worrying about your family member's health because vaccines aren't invented and the only medicine you have is herbs that can be found growing nearby.