That would be awesome in my opinion. We replaced Thor with a girl. We might replace Black Panther with his sister, We replaced Captain America with an African American, So heck yes I'm in. Just saying, I think MJ should have some sort of immunity powers and invisibility along with the extra physical strength.
In the Disney ultimate spiderman show not the recent lower quality show they gave MJ the power of a symbiot.
It just did not resonate with me. I am fine with Pepper Pots getting an iron man suit. I like an alternate version of gwen stacy with spiderman powers. Even uncle ben with spiderman powers.
Mary Jane with spiderman powers just does not fly with me.